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Exploration into Middle Molecules

Recent kidney research has revealed a group of potentially harmful disease-associated molecules, collectively called “middle molecules.” These molecules have emerged as biomarkers for both cardiovascular disease and acute kidney injury (AKI), and may even play a role in the symptoms of kidney disease patients.


Our artificial kidneys are being designed with detection and removal of middle molecules in mind. Currently, capillary electrophoresis (CE) is being utilized as a detection system to ensure that our artificial kidneys provide ample clearance of identified middle molecules such as beta-2 microglobulin (B2M).


In addition, we are performing further CE testing to elucidate the relationship between middle molecules and kidney disease.